Why the study?
Conflicting reports existed regarding IL11 in the heart, with evidence of profibrotic downstream effects of TGFβ contrasting with reports suggesting recombinant human IL11 is cardioprotective.
Does cardiomyocyte-restricted expression of IL11 induce cardiac fibrosis, inflammation, and dysfunction in a mouse model?
Population
Tamoxifen-inducible mice with cardiomyocyte-restricted murine Il11 expression
Comparison
Cardiomyocyte-restricted Il11 expression vs wild-type controls
Design
Preclinical animal study using the Cre-loxP system
Authors
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Cardiomyocyte IL11 drives fibrosis in mice; leaves open whether IL11 inhibition alters human cardiac remodeling.
Does cardiomyocyte-restricted expression of IL11 induce cardiac fibrosis, inflammation, and dysfunction in a mouse model?
Cardiomyocyte-restricted expression of IL11 in mice drives severe cardiac fibrosis, inflammation, and left ventricular dysfunction, challenging previous reports of its cardioprotective potential.
Sweeney et al. (2023) studied this question.
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