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March 5, 2003Proceedings of the National Academy of Sciences

Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration

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Why the study?

Does activation of the natriuretic peptide/cGMP/cGK pathway improve angiogenesis and vascular regeneration in models of tissue ischemia?

Population

Mouse models of operatively induced hindlimb ischemia and cultured human umbilical vein endothelial cells.

Comparison

Overexpression of BNP, overexpression of cGKI… vs Non-transgenic control littermates…

Design

Preclinical, Mice were randomly allotted to four treatment groups

Follow-up

Up to 28 days for in vivo ischemia models

Authors

KYKenichi YamaharaHyogo Medical UniversityHIHiroshi ItohPreventive CardiologyTCTae‐Hwa ChunDiabetes Australia

Discussion

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Implication

Supports BNP/cGMP pathway in ischemic angiogenesis; leaves open translation to human vascular regeneration therapies.

Structured PICO

Does activation of the natriuretic peptide/cGMP/cGK pathway improve angiogenesis and vascular regeneration in models of tissue ischemia?

P
Population
Mouse models of operatively induced hindlimb ischemia (BNP-Tg mice, cGKI-knockout mice, cGKI-Tg mice, 10-15 weeks old) and cultured human umbilical vein endothelial cells.
I
Intervention
Overexpression of BNP, overexpression of cGKI, or local CNP gene transfer (pAC.CMV-CNP plasmid) in the ischemic hindlimb; in vitro treatment with ANP, BNP, or CNP.
C
Comparator
Non-transgenic control littermates, cGKI-knockout mice, or empty vector (pAC.CMV) injection; in vitro controls.
O
Outcome
Angiogenesis and vascular regeneration assessed by hindlimb blood flow recovery (laser Doppler perfusion imaging) and capillary density.surrogate

The natriuretic peptide/cGMP/cGK pathway promotes angiogenesis and vascular regeneration in response to tissue ischemia, suggesting a potential therapeutic strategy for ischemic diseases.

Cite This Study

Yamahara et al. (2003) studied this question.

synapsesocial.com/papers/6a72281cabc331a85807b6c2https://doi.org/10.1073/pnas.0538059100
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