Why the study?
Does adenovirus-mediated gene transfer of C-type natriuretic peptide improve reendothelialization and reduce thrombogenicity and neointimal hyperplasia in rabbit vein grafts?
Population
Autologous rabbit jugular vein grafts interposed in the carotid artery, and human coronary artery…
Comparison
Ex vivo incubation in a solution of adenovirus… vs Ex vivo incubation in a solution of adenovirus…
Design
Preclinical
Follow-up
28 days
Authors
Loading...
Supports CNP gene therapy development in preclinical vein graft models; leaves open translation to human bypass surgery.
Does adenovirus-mediated gene transfer of C-type natriuretic peptide improve reendothelialization and reduce thrombogenicity and neointimal hyperplasia in rabbit vein grafts?
Adenovirus-mediated gene transfer of CNP accelerates reendothelialization and suppresses thrombosis and neointimal hyperplasia in a rabbit vein graft model, suggesting a potential strategy to prevent vein graft disease.
Ohno et al. (2002) studied this question.