Why the study?
Do anti-arrhythmic medications increase non-cardiac mortality compared to non-arrhythmic therapy?
Population
15 randomized controlled trials pooling 18,728 patients
Comparison
Anti-arrhythmic medications (AAMs) as a class vs Non-arrhythmic therapy (AV nodal blocking…
Design
Meta-analysis
Authors
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AAMs increase non-cardiac mortality; extends known cardiac harm to broader safety profile in RCTs.
Do anti-arrhythmic medications increase non-cardiac mortality compared to non-arrhythmic therapy?
Anti-arrhythmic medications are associated with a significantly increased risk of non-cardiac and all-cause mortality compared to non-arrhythmic therapies.
Pandya et al. (2016) studied this question.
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