This preclinical study demonstrates that active cation transport in embryonic chick myocardium is sensitive to ouabain and relatively insensitive to hypothermia and early anoxia.
Answers are grounded in this paper and cite their sources.
Should not alter clinical ion transport management; hypothesis-generating for ouabain effects in developing myocardium.
An active cation transport mechanism is believed to exist in embryonic chick myocardium by at least 2 days incubation. Classical effects of ouabain on unidirectional Na and K movements and contents are demonstrated in isolated ventricles of the developing embryo and hatched chick. In addition to inhibiting active Na extrusion and K entry, a marked stimulation of a passive Na in-K out exchange mechanism is indicated. Ouabain's actions on Na and K movements are believed to be primarily toxic manifestations. Hypothermia inhibits K influx and efflux equally between 30° and 20°C. Not until temperatures of 10° and 5°C are reached do Q 10 's for influx become greater than for efflux. Effects of anoxia on cation movements in young embryos are small, but increase greatly at older ages. Active transport of Na and K is sensitive to ouabain and relatively insensitive to hypothermia at all ages tested. It is relatively insensitive to anoxia at early ages. Changes in ventricular cation content are given for all conditions.
No takes yet. Share an insight, caveat, or question.
Klein et al. (1961) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: