Tocainide is an orally effective antiarrhythmic agent similar to lidocaine that suppresses ventricular arrhythmias with a favorable hemodynamic profile but frequent minor side effects.
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May support tocainide evaluation for ventricular arrhythmias; leaves open need for randomized confirmation.
Tocainide is an orally effective antiarrhythmic agent, structurally and pharmacologically similar to lidocaine. It appears to be free of marked negative hemodynamic or electrophysiologic effects in patients with heart disease, despite a high frequency of minor and often transient central nervous system and gastrointestinal side effects. Tocainide is effective in suppressing ventricular arrhythmias in a variety of settings. This agent may be a useful addition to our antiarrhythmic armamentarium.
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Alpert et al. (1983) studied this question.
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