January 21, 2011Circulation ResearchOpen Access

Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor −/− Mice

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Why the study?

Does endothelial cell-specific deficiency of AT1a receptors attenuate Ang II-induced ascending aortic aneurysms in LDL receptor -/- mice?

Structured PICO

Does endothelial cell-specific deficiency of AT1a receptors attenuate Ang II-induced ascending aortic aneurysms in LDL receptor -/- mice?

Population

Male LDL receptor(-/-) mice fed a saturated fat-enriched diet for 1 week before osmotic mini-pump implantation

Intervention

Angiotensin II (1000 ng/kg per minute) infusion for 28 days in mice with whole body, bone marrow-derived, smooth muscle-specific, or endothelial-specific AT(1a) receptor deficiency

Comparator

Saline infusion and/or AT(1a) receptor(+/+) mice

Outcome

Intimal surface areas of ascending aortas to quantify ascending aortic aneurysmssurrogate

Angiotensin II promotes ascending aortic aneurysms specifically via stimulation of AT1a receptors on endothelial cells, highlighting a potential cellular target for aneurysm prevention.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Endothelial AT1a targeting merits further preclinical study; leaves open translation to human ascending aortic aneurysm prevention.

Cite This Study

Rateri et al. (2011) studied this question.

synapsesocial.com/papers/6a722ab3ac440176ef2a8b33 https://doi.org/10.1161/circresaha.110.222844

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Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor −/− Mice

Structured PICO

Discussion

Implication

Cite This Study

Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor −/− Mice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider