Why the study?
Does AT1a receptor deficiency in the host vascular wall or bone marrow prevent Angiotensin II-induced atherosclerosis in ApoE-/- mice?
Population
Apolipoprotein E-knockout mice with or without bone marrow AT1a receptor generated by experimental bone…
Comparison
Angiotensin II infusion via osmotic pump for 7… vs Phosphate-buffered saline (PBS) infusion
Design
Preclinical
Follow-up
4 weeks
Authors
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May prioritize vascular over bone marrow AT1a for atherosclerosis studies; leaves open human translation.
Does AT1a receptor deficiency in the host vascular wall or bone marrow prevent Angiotensin II-induced atherosclerosis in ApoE-/- mice?
AT1a receptors in the host vascular wall, but not in the bone marrow, are essential for initiating Angiotensin II-induced atherogenesis by regulating oxidative stress and inflammatory molecule expression.
Koga et al. (2008) studied this question.
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