What does this research mean for the field?

Disruption of bone marrow angiotensin II type 1a receptor significantly reduces aortic atherosclerotic lesions and enhances plaque stability in ApoE-deficient mice. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 25, 2007Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Critical Role of Bone Marrow Angiotensin II Type 1 Receptor in the Pathogenesis of Atherosclerosis in Apolipoprotein E–Deficient Mice

Q: What are the key findings of this study?

Disruption of bone marrow AT1aR in chimeric mice resulted in significantly less atherosclerotic lesions in the aorta (P<0.05) and more stable plaques compared to mice with AT1aR-positive bone marrow.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Atherosclerosis. Intervention: Disruption of bone marrow AT1aR vs. AT1aR-positive bone marrow. Primary outcome: Atherosclerotic lesions in aorta (p=<0.05).

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Key result

Bone marrow AT1aR disruption in mice reduces aortic atherosclerotic lesions and increases plaque stability.

P<0.05

Why the study?

Does disruption of AT1R in bone marrow reduce atherosclerosis in ApoE-/- mice?

Population

Apolipoprotein E-deficient (ApoE-/-) mice and bone marrow chimeric mice

Comparison

Genetic ablation or pharmacological blockade of… vs Mice with AT1aR-positive bone marrow

Design

Preclinical

Authors

DFDaiju FukudaInterventional Cardiology MSMasataka SataVascular Medicine NINobukazu IshizakaDoai Memorial Hospital

Discussion

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Implication

Suggests bone marrow AT1aR as atherosclerosis target; leaves open translation to clinical practice.

Structured PICO

Does disruption of AT1R in bone marrow reduce atherosclerosis in ApoE-/- mice?

Population

ApoE-/- mice and bone marrow chimeric mice used to study the role of AT1R in bone marrow in the pathogenesis of atherosclerosis.

Intervention

Genetic ablation or pharmacological blockade of AT1R, and disruption of AT1aR in bone marrow

Comparator

Mice with AT1aR-positive bone marrow

Outcome

Atherosclerotic lesion size and plaque stabilitysurrogate

Main Result

p-value: p=<0.05

Bone marrow AT1R plays a critical role in the pathogenesis and progression of atherosclerosis, highlighting a specific cellular mechanism for angiotensin II-mediated vascular disease.

Cite This Study

Fukuda et al. (2007) studied Atherosclerosis. Disruption of bone marrow AT1aR vs. AT1aR-positive bone marrow was evaluated on Atherosclerotic lesions in aorta (p=<0.05). Disruption of bone marrow AT1aR in chimeric mice resulted in significantly less atherosclerotic lesions in the aorta (P<0.05) and more stable plaques compared to mice with AT1aR-positive bone marrow.

synapsesocial.com/papers/6aa81fd487c5c9fcf5da0cb8 https://doi.org/10.1161/atvbaha.107.152363

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Critical Role of Bone Marrow Angiotensin II Type 1 Receptor in the Pathogenesis of Atherosclerosis in Apolipoprotein E–Deficient Mice

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Critical Role of Bone Marrow Angiotensin II Type 1 Receptor in the Pathogenesis of Atherosclerosis in Apolipoprotein E–Deficient Mice

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider