Why the study?
To develop a new method for evaluating the inhibitory effect of aspirin on platelets using three-dimensional morphological parameters.
Does 3D morphological analysis accurately evaluate the inhibitory effect of aspirin on platelet aggregation in healthy volunteer blood samples?
Does 3D morphological analysis accurately evaluate the inhibitory effect of aspirin on platelet aggregation in healthy volunteer blood samples?
A novel 3D morphological analysis method demonstrates better accuracy and sensitivity than standard LTA for evaluating the inhibitory effect of aspirin on platelet aggregation in vitro.
May enable alternative aspirin response assessment; leaves open clinical utility pending validation studies.
OBJECTIVE: To develop a new method for evaluating the inhibitory effect of aspirin on platelet by the three-dimensional (3D) morphological parameters. METHODS: The sodium citrate-anticoagulant peripheral blood samples collected from 12 healthy volunteers were divided into 2 groups: group treated with 200 μmol/L acetylsalicylic acid (ASA), and control group. The platelets in the 2 groups were washed and purified. The purified platelets were added into reaction pools modified with type I collagen and induced to activation and aggregation under static condition. The 3D morphology of the formed platelet aggregate was measured by the laser shape microscopic system. Meanwhile, the platelet function was detected by turbidometric light transmittance aggregometry (LTA). CONCLUSION: The new method developed for evaluating the ASA inhibition of platelet aggregation may provide a complementary strategy for researching and clinically evaluating of ASA anti-platelet aggregation in future.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: