Key result
Ingestion of 325 mg aspirin resulted in a 45% mean reduction in platelet deposition in whole blood perfused over collagen in 27 of 28 healthy individuals (P < 0.001).
Why the study?
Does aspirin ingestion or ex vivo addition reduce platelet deposition on collagen in whole blood from healthy individuals?
Does aspirin ingestion or ex vivo addition reduce platelet deposition on collagen in whole blood from healthy individuals?
Effect estimate: 45% mean reduction
p-value: p=< 0.001
A microfluidic device successfully quantified the reduction in platelet deposition following aspirin ingestion or ex vivo addition, demonstrating utility for assessing inter-individual response to aspirin.
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Aspirin reduced collagen-induced platelet deposition in healthy blood; supports microfluidic testing of antiplatelet response but leaves clinical utility open.
Li et al. (2013) studied Healthy (n=28). Acetylsalicylic acid (aspirin) vs. Before treatment (baseline) was evaluated on Platelet deposition (45% mean reduction, p=< 0.001). Ingestion of 325 mg aspirin resulted in a 45% mean reduction in platelet deposition in whole blood perfused over collagen in 27 of 28 healthy individuals (P < 0.001).
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