Action of Aspirin on Whole Blood-Aggregation Evaluated by the Screen Filtration Pressure Method
View Full Paper
Ask AI
Bookmark
Share
Key result
Aspirin intake of 100 mg/day for 14 days significantly decreased the maximal platelet aggregation rate induced by 1.6 mg/L collagen from 85.5% to 51.5%.
Why the study?
Does aspirin 100 mg/day alter whole-blood aggregation as measured by the screen filtration pressure method in healthy male volunteers?
Population
35 healthy male volunteers, aged 26-48 years, based in Japan. Key inclusion: no drugs affecting platelet…
Design
Cohort
Follow-up
14 days (21 days for a subset of 9 subjects)
Authors
Discussion
Loading...
Member takes
Implication
Supports screen filtration pressure method as surrogate for aspirin monitoring in healthy volunteers; leaves open translation to patients or outcomes.
Structured PICO
Does aspirin 100 mg/day alter whole-blood aggregation as measured by the screen filtration pressure method in healthy male volunteers?
P
Population
35 healthy male physicians aged 26 to 48 years who took 100 mg/day aspirin for 14 days to evaluate platelet aggregation.
I
Intervention
Aspirin 100 mg oral once daily after breakfast for 14 days. A subset of 9 subjects subsequently took 300 mg/day for an additional 7 days.
O
Outcome
Platelet-aggregation threshold index (PATI) for whole blood and platelet-rich plasma (PRP) using collagen and adenosine diphosphate (ADP), and maximal aggregation rate at baseline, day 7, and day 14.surrogate
Main Result
Absolute Event Rate: 51.5% vs 85.5%
p-value: p=<0.0001
Whole-blood aggregation measured by the screen filtration pressure method is a feasible and accurate surrogate marker for monitoring the antiplatelet efficacy of aspirin therapy.
Limitations
- Small sample size
- Only healthy male volunteers included
- Unknown if results are directly applicable to patients with cardiovascular disease
- Whether the results derived from healthy volunteers are directly applicable to actual patients with cardiovascular disease is unknown and deserves further study.
Cite This Study
Tabuchi et al. (2008) studied Healthy volunteers (n=35). Aspirin vs. Baseline (pre-intervention) was evaluated on Maximal aggregation rate induced by 1.6 mg/L collagen (p=<0.0001). Aspirin intake of 100 mg/day for 14 days significantly decreased the maximal platelet aggregation rate induced by 1.6 mg/L collagen from 85.5% to 51.5%.
Topics
View Full Paper
Ask AI
Bookmark
Share