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February 1, 1970Experimental Biology and Medicine

On the Mechanism of Platelet Function Inhibition by Acetylsalicylic Acid,

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Population

Platelets (preclinical model)

Design

Preclinical

Authors

HAHamid Al‐MondhiryUniversity of North Carolina at Chapel HillAMA J MarcusHouston MethodistTSTheodore H. SpaetAlbert Einstein College of Medicine

Discussion

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Overview

Cautions against clinical extrapolation from animals; extends preclinical support for acetylation-dependent platelet effects.

Key Points

  • To investigate how acetylsalicylic acid alters platelet function and identify mechanisms involved.
  • Examined platelet aggregation in response to ADP, epinephrine, and collagen after treatment with aspirin and acetic anhydride.
  • Attempted to track acetylation of platelets using acetyl-1-14C salicylic acid.
  • Aspirin caused loss of platelet aggregation in response to ADP and epinephrine (specific effects noted).
  • Collagen-mediated aggregation was inhibited, indicating aspirin's broad effects on platelet function.
  • No successful identification of specific acetylation in platelets despite label incorporation, leaving a question on metabolic pathways.

Structured PICO

P
Population
Platelets (preclinical model)
I
Intervention
Acetylsalicylic acid (aspirin) and acetic anhydride
O
Outcome
Platelet function alteration (aggregation response to ADP, epinephrine, collagen; platelet factor 3 release)surrogate

This early mechanistic study supports the hypothesis that aspirin inhibits platelet function via acetylation.

Limitations

  • Metabolic incorporation of acetate could not be excluded when attempting to identify specific acetylation with acetyl-1-14C salicylic acid.

Cite This Study

Al‐Mondhiry et al. (1970) studied this question.

synapsesocial.com/papers/6a7930b306f2b779205ae130https://doi.org/10.3181/00379727-133-34533
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.1975 · 865 citations
  2. 2Platelet Function1969 · 37 citations
  3. 3Inhibition of Adenosine Diphosphate-Induced Secondary Aggregation and Other Platelet Functions by Acetylsalicylic Acid Ingestion1968 · 325 citations
  4. 4The influence of salicylate on platelets and whole blood adenine nucleotides1969 · 8 citations
  5. 5Platelet Aggregation and Release by ADP and Thrombin: Evidence for Two Separate Effects of ADP on Platelets, Involvement of Fibrinogen in Release, and Mechanism of Inhibitory Action of Acetylsalicylic Acid1974 · 20 citations