March 1, 1974British Journal of Haematology

Platelet Aggregation and Release by ADP and Thrombin: Evidence for Two Separate Effects of ADP on Platelets, Involvement of Fibrinogen in Release, and Mechanism of Inhibitory Action of Acetylsalicylic Acid

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Population

Platelets (preclinical/in vitro model)

Design

Preclinical

Authors

NAN.G. ArdlieSouth Australia Pathology

Discussion

Member takes

Implication

May refine aspirin’s antiplatelet mechanisms; hypothesis-generating from animal data and should not change practice.

Structured PICO

Population

Platelets (preclinical/in vitro model)

Intervention

ADP, thrombin, fibrinogen, and acetylsalicylic acid (aspirin)

Outcome

Platelet aggregation, release reaction, and morphological changessurrogate

This preclinical study elucidates the dual role of ADP in platelet aggregation and suggests aspirin inhibits platelet function by acetylating thrombin or prothrombin.

Cite This Study

N.G. Ardlie (1974) studied this question.

synapsesocial.com/papers/6a8227fdce1b06b06574a798 https://doi.org/10.1111/j.1365-2141.1974.tb00478.x

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Platelet Aggregation and Release by ADP and Thrombin: Evidence for Two Separate Effects of ADP on Platelets, Involvement of Fibrinogen in Release, and Mechanism of Inhibitory Action of Acetylsalicylic Acid

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Platelet Aggregation and Release by ADP and Thrombin: Evidence for Two Separate Effects of ADP on Platelets, Involvement of Fibrinogen in Release, and Mechanism of Inhibitory Action of Acetylsalicylic Acid

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider