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July 1, 1997Human ReproductionOpen Access

Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production

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Why the study?

Does low-dose aspirin prevent miscarriage in pregnant women with a history of recurrent spontaneous abortion?

Population

66 pregnant women with a history of recurrent spontaneous abortion, including 12 with elevated and 54 with…

Comparison

Low-dose aspirin administered from a mean of 6.6… vs Placebo administered from a mean of 6.6 days…

Design

RCT, Randomized

Follow-up

To delivery

Authors

MTMaija TulppalaMMMerja B. MarttunenVSViveca Söderström‐Anttila

Discussion

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Overview

Low-dose aspirin should not be used to prevent miscarriage in recurrent spontaneous abortion; confirms lack of benefit despite effective TXA2 inhibition.

Structured PICO

Does low-dose aspirin prevent miscarriage in pregnant women with a history of recurrent spontaneous abortion?

P
Population
66 pregnant women with a history of recurrent spontaneous abortion (RSA), including 12 with elevated and 54 with normal anticardiolipin antibodies (ACA) concentrations.
I
Intervention
Low-dose aspirin (50 mg/day) administered from a mean of 6.6 days after the missed period to delivery.
C
Comparator
Placebo administered from a mean of 6.6 days after the missed period to delivery.
O
Outcome
Pregnancy outcome (miscarriage) and production of prostacyclin (PGI2) and thromboxane A2 (TXA2).hard clinical

Low-dose aspirin effectively inhibits thromboxane A2 production but does not improve pregnancy outcomes in women with recurrent spontaneous abortion.

Cite This Study

Tulppala et al. (1997) studied this question.

synapsesocial.com/papers/6a722e3535aa2c282ce31ff7https://doi.org/10.1093/humrep/12.7.1567
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