Key result
Low dose aspirin significantly reduced the incidence of pre-eclampsia (6% vs 13%), preterm birth (8% vs 17%), and small for gestational age (19% vs 32%) compared to the control group.
Why the study?
Pregnancy is associated with complications such as pre-eclampsia, SGA, and preterm birth, and low dose aspirin is a potential medication to minimize these adverse outcomes.
Does low dose aspirin reduce adverse pregnancy outcomes in pregnant women?
Cross-Sectional (n=200)
Yes
Does low dose aspirin reduce adverse pregnancy outcomes in pregnant women?
Absolute Event Rate: 6% vs 13%
p-value: p=0.0384
Low dose aspirin significantly reduces the risk of adverse pregnancy outcomes, including gestational hypertension, pre-eclampsia, preterm birth, and small for gestational age.
May support low-dose aspirin in pregnancy; hypothesis-generating from cross-sectional data, RCTs needed before practice change.
Background: Pregnancy is associated with various complications such as pre-eclampsia, SGA, preterm birth etc. Low dose aspirin is a possible medication to minimize these adverse outcomes. The aim of this study was to evaluate the use of low dose aspirin for primary prevention of adverse pregnancy outcome. Material Methods: This cross-sectional study was conducted in department of Gynaecology, North Bengal Medical College Hospital, Mirjapur Bkash Hospital, Mirjapur, Tangail, Bangladesh, during the period from June 2021 to August 2022. Total 200 pregnant women were included in this study. Results: In this study, the mean (±SD) age of the study subjects were 25.12 ± 5.49 years and 25.00 ± 4.83 years in LDA group and control group, respectively. There was no statistically significant (p>0.05) difference in age between the groups. The rate of caesarean section was higher in control group (68%) compared to LDA group (59%) but there was no statistically significant (p>0.05) difference among the groups. In our study, 8% pregnant women in LDA group and 19% pregnant women in control group had gestational hypertension, pre-eclampsia was seen in 6% and 13% pregnant women in LDA group and control group, respectively, preterm birth was seen in 8% and 17% pregnant women in LDA group and control group, respectively, SGA was seen in 19% and 32% pregnant women in LDA group and control group, respectively, and fetal distress was seen in 2% pregnant women in both LDA group and control group. There were statistically significant (p<0.05) differences in complications except fetal distress. Mean (±SD) neonatal birth weight was 2.88±1.03 kg and 2.74±0.85 kg in LDA group and control group, respectively and there was no statistically significant (p>0.05) difference. Conclusion: We found that low dose aspirin could significantly reduce the risk of adverse outcomes, especially for pre-eclampsia, SGA and preterm birth.
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Akther et al. (2023) conducted a cross-sectional in Pregnancy (n=200). Low dose aspirin vs. Control group was evaluated on Pre-eclampsia (p=0.0384). Low dose aspirin significantly reduced the incidence of pre-eclampsia (6% vs 13%), preterm birth (8% vs 17%), and small for gestational age (19% vs 32%) compared to the control group.
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