December 1, 2017Open Access

Predictors of super-response to cardiac resynchronization therapy: the significance of heart failure medication, pre-implant left ventricular geometry and high percentage of biventricular pacing.

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Why the study?

Do baseline ACEI/ARB use, lower LVEDV, and >98% biventricular pacing improve the likelihood of super-response in patients undergoing cardiac resynchronization therapy?

Population

201 patients who underwent cardiac resynchronization therapy (CRT) between 2010 and 2014

Design

Cohort

Follow-up

6 months

Authors

HJHan JinTianjin University of Technology and Education MGMin GuChongqing University WHWei HuaNorthern Jiangsu People's Hospital

Discussion

Member takes

Implication

Identified predictors of CRT super-response may refine candidate selection; leaves open prospective validation before practice change.

Structured PICO

Do baseline ACEI/ARB use, lower LVEDV, and >98% biventricular pacing improve the likelihood of super-response in patients undergoing cardiac resynchronization therapy?

Population

201 patients who underwent cardiac resynchronization therapy (CRT) between 2010 and 2014

Intervention

Cardiac resynchronization therapy (CRT) with evaluation of baseline and post-implant predictors (ACEI/ARB use, baseline left ventricular geometry, biventricular pacing percentage)

Outcome

Super-response to CRT (defined as a decrease in NYHA functional class ≥ 1, a decrease in left ventricular end-systolic volume [LVESV] ≥ 15%, and a final left ventricular ejection fraction [LVEF] ≥ 45%) at 6 monthscomposite

Lower baseline left ventricular end-diastolic volume, use of ACEI/ARB, and >98% biventricular pacing are independent predictors of super-response to cardiac resynchronization therapy at 6 months.

Cite This Study

Jin et al. (2017) studied this question.

synapsesocial.com/papers/6a7236c2a528af2d65c45917 https://doi.org/10.11909/j.issn.1671-5411.2017.12.003

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Predictors of super-response to cardiac resynchronization therapy: the significance of heart failure medication, pre-implant left ventricular geometry and high percentage of biventricular pacing.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Predictors of super-response to cardiac resynchronization therapy: the significance of heart failure medication, pre-implant left ventricular geometry and high percentage of biventricular pacing.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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