Why the study?
Cerebral blood flow is commonly inferred from middle cerebral artery blood velocity alone, but measuring vessel diameter is also critical given mounting evidence that the artery is vasoactive.
Does imaging transcranial Doppler ultrasound accurately quantify changes in middle cerebral artery blood flow during nitroglycerin-induced vasodilation in healthy participants?
Population
13 healthy participants (7 men/6 women; 28 ± 5 yr)
Comparison
Nitroglycerin 0.8 mg vs sham delivery (CON)
Follow-up
5 min following NTG or sham delivery
Authors
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Challenges velocity-only TCD assumptions; leaves open whether ITCD improves clinical CBF accuracy.
Does imaging transcranial Doppler ultrasound accurately quantify changes in middle cerebral artery blood flow during nitroglycerin-induced vasodilation in healthy participants?
Imaging transcranial Doppler ultrasound demonstrates that measuring both middle cerebral artery blood velocity and diameter is critical for accurately assessing cerebral blood flow, as velocity alone may decrease while total flow increases during vasodilation.
Jarrett et al. (2020) studied this question.
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