December 1, 1993Journal of VirologyOpen Access

Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor

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Population

Cultured primary duck hepatocytes and duck hepatitis B virus (DHBV)

Design

Preclinical

Authors

UKUrsula KlingmüllerGerman Cancer Research Center HSHeinz SchallerDarmstadt University of Applied Sciences

Discussion

Member takes

Implication

Supports pre-S targeting for entry inhibitors; leaves open translation beyond avian models.

Structured PICO

Population

Cultured primary duck hepatocytes and duck hepatitis B virus (DHBV)

Intervention

Subviral particles containing DHBV surface proteins (pre-S/S protein vs small S protein) produced in Saccharomyces cerevisiae

Outcome

Viral infectivity and physical binding to hepatocytessurrogate

Hepadnaviral infection is initiated by specific attachment of the pre-S domain of the large envelope protein to a limited number of hepatocellular binding sites.

Cite This Study

Klingmüller et al. (1993) studied this question.

synapsesocial.com/papers/6a72392c87f9210571287f95 https://doi.org/10.1128/jvi.67.12.7414-7422.1993

View Full Paper

Ask AI

Bookmark

Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider