Why the study?
Deletion of the EP402R gene led to attenuation of various ASFV strains, but the degree of attenuation varies among different isolates.
Does deletion of the CD2 gene in the ASFV Congo strain affect virulence and viremia in domestic swine?
Does deletion of the CD2 gene in the ASFV Congo strain affect virulence and viremia in domestic swine?
Deletion of the CD2 gene in the ASFV Congo strain delays disease onset and viremia but does not attenuate virulence, indicating that the effect of this deletion depends on the viral genetic background.
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Advances ASF vaccine candidates via gene deletion; leaves open field efficacy and safety in swine.
Koltsov et al. (2023) studied this question.
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