Key result
Deletion of the 8DR gene from the genome of the highly virulent ASFV Georgia isolate does not significantly alter virus virulence or lethality in domestic pigs.
Why the study?
Natural ASFV isolates with decreased virulence in swine are non-hemadsorbing, suggesting an association between altered or deleted forms of the CD2-like 8DR gene and virus attenuation.
Absolute Event Rate: 0% vs 0%
Deletion of the CD2-like gene (8DR) from the highly virulent ASFV Georgia strain does not attenuate its virulence in domestic swine, indicating it may not be a suitable single-deletion target for live-attenuated vaccine development for this strain.
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Links 8DR alterations to ASFV attenuation in swine; leaves open targeted vaccine attenuation strategies.
Borca et al. (2020) studied African swine fever (n=46). ASFV-G-Δ8DR (8DR gene deletion mutant) vs. Parental ASFV-G was evaluated on Survival / Lethality. Deletion of the 8DR gene from the genome of the highly virulent ASFV Georgia isolate does not significantly alter virus virulence or lethality in domestic pigs.
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