July 28, 2021VirusesOpen Access

Deletion of the K145R and DP148R Genes from the Virulent ASFV Georgia 2007/1 Isolate Delays the Onset, but Does Not Reduce Severity, of Clinical Signs in Infected Pigs

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Why the study?

Many of the approximately 160 proteins coded by African swine fever virus have unknown functions, hindering understanding of virus and host interactions.

Structured PICO

Population

Porcine macrophages and pigs

Intervention

Infection with African swine fever virus (ASFV) virulent genotype II Georgia 2007/1 isolate with deletion of the DP148R gene, alone or in combination with the K145R gene

Comparator

Infection with parental wild-type ASFV Georgia 2007/1 isolate

Outcome

Virus replication in macrophages and virulence (clinical signs and viremia) in pigs

Deletion of the K145R and DP148R genes from the ASFV Georgia 2007/1 isolate delays the onset of clinical signs but does not reduce the overall severity of the disease in pigs.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Attenuates ASFV virulence in pigs; leaves open vaccine candidate development pending field trials.

Cite This Study

Rathakrishnan et al. (2021) studied this question.

synapsesocial.com/papers/6a8a7d1f06e1858e55de90ad https://doi.org/10.3390/v13081473

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Deletion of the K145R and DP148R Genes from the Virulent ASFV Georgia 2007/1 Isolate Delays the Onset, but Does Not Reduce Severity, of Clinical Signs in Infected Pigs

Structured PICO

Discussion

Implication

Cite This Study

Deletion of the K145R and DP148R Genes from the Virulent ASFV Georgia 2007/1 Isolate Delays the Onset, but Does Not Reduce Severity, of Clinical Signs in Infected Pigs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider