Key result
Immunization with the BeninΔDP148R virus protected 11 of 11 pigs vaccinated intramuscularly and 5 of 6 vaccinated intranasally against challenge with virulent African swine fever virus.
Deletion of the DP148R gene from the African swine fever virus reduces virulence and induces high levels of protection against challenge, providing a potential target for vaccine development.
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DP148R may contribute to ASFV virulence in vivo; leaves open its utility for live-attenuated vaccine development.
Reis et al. (2017) studied African swine fever. BeninΔDP148R virus immunization vs. Control nonimmune pigs was evaluated on Survival following challenge with parental virulent virus. Immunization with the BeninΔDP148R virus protected 11 of 11 pigs vaccinated intramuscularly and 5 of 6 vaccinated intranasally against challenge with virulent African swine fever virus.
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