Why the study?
Does diet-induced obesity exacerbate cardiac hypertrophy and dysfunction following pressure overload in mice?
Population
WT male mice fed a normal chow or high-fat diet for 10 weeks prior to surgery
Comparison
Transverse aortic constriction in diet-induced… vs Transverse aortic constriction in chow-fed mice…
Design
Preclinical
Follow-up
5-6 weeks after surgery
Authors
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May improve translational relevance of HF models to obese patients; leaves open clinical applicability pending further validation.
Does diet-induced obesity exacerbate cardiac hypertrophy and dysfunction following pressure overload in mice?
Diet-induced obesity aggravates the progression of cardiac hypertrophy and heart failure caused by pressure overload, highlighting the importance of cardiometabolic state in HF pathogenesis.
Holzem et al. (2015) studied this question.
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