Key result
A short duration of high-fat diet induced insulin resistance and significantly decreased survival (43% vs 75%) and exacerbated left ventricular dysfunction after pressure overload in mice.
Why the study?
Does a short duration of high-fat diet exacerbate adverse left ventricular remodeling and dysfunction after pressure overload in C57BL6 male mice?
Population
C57BL6 male mice, starting at 7 weeks of age.
Comparison
High-fat diet for 9 days followed by transverse… vs Standard diet for 9 days followed by transverse…
Design
Preclinical
Follow-up
28 days after TAC
Authors
Loading...
May warrant dietary caution in cardiac stress; leaves open human relevance of insulin resistance in pressure overload.
Does a short duration of high-fat diet exacerbate adverse left ventricular remodeling and dysfunction after pressure overload in C57BL6 male mice?
Absolute Event Rate: 43% vs 75%
p-value: p=<0.02
A short duration of high-fat diet induces insulin resistance and exacerbates adverse left ventricular remodeling, dysfunction, and mortality following pressure overload in mice.
Raher et al. (2008) studied Left ventricular pressure overload. High-fat diet vs. Standard diet (10% fat) was evaluated on Survival after transverse aortic constriction (p=<0.02). A short duration of high-fat diet induced insulin resistance and significantly decreased survival (43% vs 75%) and exacerbated left ventricular dysfunction after pressure overload in mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: