Key result
A short duration of high-fat diet induced insulin resistance and significantly decreased survival (43% vs 75%) and exacerbated left ventricular dysfunction after pressure overload in mice.
Why the study?
Does a short duration of high-fat diet exacerbate adverse left ventricular remodeling and dysfunction after pressure overload in C57BL6 male mice?
Does a short duration of high-fat diet exacerbate adverse left ventricular remodeling and dysfunction after pressure overload in C57BL6 male mice?
Absolute Event Rate: 43% vs 75%
p-value: p=<0.02
A short duration of high-fat diet induces insulin resistance and exacerbates adverse left ventricular remodeling, dysfunction, and mortality following pressure overload in mice.
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May warrant dietary caution in cardiac stress; leaves open human relevance of insulin resistance in pressure overload.
Raher et al. (2008) studied Left ventricular pressure overload. High-fat diet vs. Standard diet (10% fat) was evaluated on Survival after transverse aortic constriction (p=<0.02). A short duration of high-fat diet induced insulin resistance and significantly decreased survival (43% vs 75%) and exacerbated left ventricular dysfunction after pressure overload in mice.
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