December 2, 2016European Heart Journal - Cardiovascular Imaging
Short-term high-fat diet compromises myocardial function: a radial strain rate imaging study
Key result
High-fat diet impairs early LV function, reducing radial strain rate ~22% vs chow diet.
- P<0.001
- n=33
Why the study?
Long-term high-fat diet induces cardiac remodelling and myocardial dysfunction in murine models, but the time course and mechanisms of short-term effects are unclear.
Does a short-term high-fat diet compromise myocardial function in wild-type mice?
Comparison
High-fat diet (60% fat) vs chow diet (13% fat)
Design
Preclinical study
Follow-up
20 weeks
Authors
Discussion
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Member takes
Implication
Early HFD effects in mice should not alter practice; leaves open human translation of rapid myocardial changes.
Structured PICO
Does a short-term high-fat diet compromise myocardial function in wild-type mice?
P
Population
33 wild-type mice subjected to high-fat diet or chow diet and followed for 20 weeks.
I
Intervention
High-fat diet (HFD, 60% fat) for 20 weeks
C
Comparator
Chow diet (CD, 13% fat) for 20 weeks
O
Outcome
Metabolic and cardiac modifications including left ventricular (LV) diameters and thickness, systolic function using radial strain rate (SR), and histological assessmentsurrogate
Main Result
Absolute Event Rate: 21% vs 27%
p-value: p=<0.001
Short-term high-fat diet in mice induces early left ventricular dysfunction and myocardial remodeling detectable by radial strain rate imaging before changes in LV mass or blood pressure occur.
Cite This Study
Ternacle et al. (2016) studied myocardial dysfunction (n=33). High-fat diet vs. Chow diet (13% fat) was evaluated on radial strain rate (SR) at 5 weeks (p=<0.001). High-fat diet in wild-type mice induced early left ventricular dysfunction, evidenced by reduced radial strain rate (21 vs. 27 unit/s, P<0.001) at 5 weeks compared to chow diet.