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December 1, 2011Journal of Clinical HypertensionOpen Access

Markers of Inflammation, Metabolic Risk Factors, and Incident Heart Failure in American Indians: The Strong Heart Study

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Why the study?

Are elevated inflammatory markers (CRP, fibrinogen) and metabolic syndrome associated with an increased risk of incident heart failure in American Indians?

Population

3,098 American Indians without prevalent cardiovascular disease, with a high prevalence of diabetes…

Comparison

Elevated inflammatory markers and metabolic… vs Lower levels of inflammatory markers and absence…

Design

Cohort

Follow-up

mean 11 years

Authors

ABAna BaracHWHong WangNSNawar Shara

Discussion

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Member takes

Overview

Fibrinogen was associated with incident HF in American Indians; hypothesis-generating and should not yet change practice.

Structured PICO

Are elevated inflammatory markers (CRP, fibrinogen) and metabolic syndrome associated with an increased risk of incident heart failure in American Indians?

P
Population
3,098 American Indians without prevalent cardiovascular disease, with a high prevalence of diabetes, obesity, and metabolic syndrome
I
Intervention
Elevated inflammatory markers (C-reactive protein and fibrinogen) and metabolic syndrome
C
Comparator
Lower levels of inflammatory markers and absence of metabolic syndrome
O
Outcome
Incident heart failurehard clinical

In American Indians, elevated fibrinogen is an independent predictor of incident heart failure, suggesting inflammation acts in concert with metabolic risk factors to increase HF risk.

Cite This Study

Barac et al. (2011) studied this question.

synapsesocial.com/papers/6a7245c8febe604dd70a84d8https://doi.org/10.1111/j.1751-7176.2011.00560.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Syndrome, Inflammation, and Incident Heart Failure in the Elderly2008 · 84 citations
  2. 2C-Reactive Protein in Heart Failure2005 · 457 citations
  3. 3C-Reactive Protein Overexpression Exacerbates Pressure Overload–Induced Cardiac Remodeling Through Enhanced Inflammatory Response2011 · 71 citations
  4. 4Diagnosis and Management of the Metabolic Syndrome2005 · 11,930 citations
  5. 5C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes2005 · 102 citations