Key result
Metabolic syndrome and elevated inflammation markers were independently associated with increased risk of incident heart failure (HR 1.32 for MetS; HR 1.53 for CRP; HR 1.37 for IL-6).
Why the study?
Do metabolic syndrome and inflammation markers predict incident congestive heart failure in elderly adults without baseline CHF or diabetes?
Population
4017 men and women ≥65 years old, without baseline congestive heart failure or diabetes, participating in…
Comparison
Presence of metabolic syndrome and elevated… vs Absence of metabolic syndrome and/or elevated…
Design
Cohort
Follow-up
12.2 years
Authors
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May aid HF risk stratification in elderly without diabetes; leaves open causal effects and intervention benefits.
Observational (n=4,017)
Do metabolic syndrome and inflammation markers predict incident congestive heart failure in elderly adults without baseline CHF or diabetes?
Effect estimate: HR 1.32 (95% CI 1.16 to 1.51)
Incorporating inflammation markers like CRP and IL-6 into the definition of metabolic syndrome identifies more elderly individuals at high risk for incident heart failure.
Suzuki et al. (2008) conducted an observational in Incident congestive heart failure (n=4,017). Metabolic syndrome and inflammation markers (CRP, IL-6) vs. Absence of metabolic syndrome and elevated inflammation markers was evaluated on Incident congestive heart failure (HR 1.32, 95% CI 1.16 to 1.51). Metabolic syndrome and elevated inflammation markers were independently associated with increased risk of incident heart failure (HR 1.32 for MetS; HR 1.53 for CRP; HR 1.37 for IL-6).
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