Why the study?
Does short-duration rapid atrial pacing alter rate-dependent changes in atrial action potential duration in humans?
Does short-duration rapid atrial pacing alter rate-dependent changes in atrial action potential duration in humans?
Short-term rapid atrial pacing in humans induces electrical remodeling, characterized by a significant decrease in the rate-dependent adaptation of the atrial action potential duration.
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Short-term rapid atrial pacing may induce atrial electrical remodeling in humans; hypothesis-generating and leaves open clinical relevance for AF.
The effect of rapid atrial pacing on the rate adaptation of the atrial action potential duration was studied in humans. The right atrial monophasic action potential (RAMAP) of 5 patients was recorded before and after 30 min of rapid atrial pacing. The pacing cycle length (CL) was 146 +/- 9 ms, the shortest duration at which 1:1 capture was possible. The RAMAP duration at 90% repolarization (RMAPD) was measured. CL-dependent changes in RAMAPD (CL 600 ms-CL 300 ms) before and after rapid atrial pacing were 51.8 +/- 10.7 ms and 30.8 +/- 7.6 ms (p < 0.05), respectively.
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Watanabe et al. (2002) studied this question.
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