Why the study?
Are baseline BNP/NT-proBNP levels associated with the recurrence of atrial fibrillation after successful electrical cardioversion?
Are baseline BNP/NT-proBNP levels associated with the recurrence of atrial fibrillation after successful electrical cardioversion?
Baseline BNP/NT-proBNP concentrations may serve as a predictor for atrial fibrillation recurrence following successful electrical cardioversion.
May inform post-cardioversion AF recurrence risk assessment; leaves open need for BNP-guided management trials.
OBJECTIVE: To investigate the relationship between brain natriuretic peptide and recurrence of atrial fibrillation after successful electrical cardioversion. METHODS: Medline and Embase databases were used to identify publications evaluating BNP/N-Terminal (NT)-proBNP levels in association with atrial fibrillation recurrence after successful electrical cardioversion. Nineteen studies that fulfilled the specified criteria of our analysis were found. RESULTS: Baseline BNP/NT-proBNP levels of the atrial fibrillation recurrence group were significantly higher than those of the sinus rhythm maintaining group (SMD -0.70, CI [-0.82, -0.58]). CONCLUSION: Our analysis suggests that low BNP/NT-proBNP levels are associated with sinus rhythm maintenance, and baseline BNP/NT-proBNP concentrations may be a predictor of atrial fibrillation recurrence after successful electrical cardioversion.
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Xu et al. (2017) studied this question.
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