Why the study?
Immune checkpoint inhibitor therapy can cause severe myocarditis, where treatment has relied on glucocorticoids and mandated drug discontinuation despite emerging interest in alternative immunosuppressive agents and therapy rechallenge.
The review summarizes current knowledge on ICI-associated myocarditis, emphasizing endomyocardial biopsy for diagnosis and the potential for immunotherapy rechallenge in mild cases.
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Normal imaging does not exclude ICI-myocarditis; leaves open optimal diagnostic role of biopsy pending higher-level evidence.
Tedeschi et al. (2023) studied this question.
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