Why the study?
It remained unclear whether obesity traits causally affect non-communicable diseases beyond cardiometabolic conditions, and whether sex-specific differences exist in these causal effects.
Do genetically predicted obesity traits causally increase the risk of leading causes of death, and are there sex-specific differences?
Population
228,466 women and 195,041 men in the UK Biobank
Comparison
Genetically predicted BMI, WHR, and WHR adjusted for BMI
Design
Mendelian randomization study
Authors
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Obesity traits causally affect most leading mortality causes with sex differences; extends MR evidence but leaves open targeted prevention trials.
Do genetically predicted obesity traits causally increase the risk of leading causes of death, and are there sex-specific differences?
Censin et al. (2019) studied this question.
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