January 1, 2009Biological and Pharmaceutical BulletinOpen Access

In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-.BETA.-D-glucopyranoside against Coxsackie Virus B3

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Why the study?

Does Calycosin-7-O-beta-D-glucopyranoside (CCGR) improve survival and cardiac function in a murine model of CVB3-induced acute myocarditis?

Structured PICO

Does Calycosin-7-O-beta-D-glucopyranoside (CCGR) improve survival and cardiac function in a murine model of CVB3-induced acute myocarditis?

Population

140 pathogen-free inbred male BALB/c mice, 4-weeks old, weighing 14-16 g, infected with coxsackie virus B3 (CVB3) to induce acute myocarditis, and Vero cell cultures for in vitro assays.

Intervention

Calycosin-7-O-beta-D-glucopyranoside (CCGR) 24 mg/kg oral daily for 14 days (in vivo); various concentrations in culture medium (in vitro).

Comparator

Menstruum (5‰ sodiumcarboxymethyl cellulose) without drug (infected control) and Radix astragali oral solution (HQ) 10 ml/kg (positive control).

Outcome

Survival rate at 14 days.hard clinical

Calycosin-7-O-beta-D-glucopyranoside demonstrates significant antiviral activity against coxsackievirus B3, improving survival and left ventricular function in a murine model of acute viral myocarditis.

Limitations

Only tested oral administration
Low cumulative urinary excretion and low plasma concentration of CCGR in animals
Differences in pathogenesis between human and mouse models

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for CCGR in murine viral myocarditis; should not yet change clinical practice.

Cite This Study

Zhu et al. (2009) studied this question.

synapsesocial.com/papers/6a724accce524a4339c55dfe https://doi.org/10.1248/bpb.32.68

Topics

Myocarditis Echocardiography

View Full Paper

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In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-.BETA.-D-glucopyranoside against Coxsackie Virus B3

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-.BETA.-D-glucopyranoside against Coxsackie Virus B3

Structured PICO

Limitations

Discussion

Implication

Cite This Study

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