Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction.
Population
Molecular models studying the protooncogene product p95vav and heterogeneous ribonucleoprotein K (hnRNP-K)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for a receptor-to-gene expression link; requires validation in mammalian models before broader inference.
Structured PICO
P
Population
Molecular models studying the protooncogene product p95vav and heterogeneous ribonucleoprotein K (hnRNP-K)
I
Intervention
Characterization of protein interactions
O
Outcome
Stable association of p95vav with hnRNP-K and specific interaction through the SH3 domain
The study identifies hnRNP-K as a novel SH3 binding protein that interacts with p95vav, suggesting a potential signaling pathway linking cell surface receptors to gene expression regulation.
Cite This Study
Hobert et al. (1994) studied this question.