The K Protein Domain That Recruits the Interleukin 1-responsive K Protein Kinase Lies Adjacent to a Cluster of c-Src and Vav SH3-binding Sites

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Population

In vitro and in vivo cell extracts and protein models (hnRNP K protein)

Design

Preclinical

Authors

Discussion

May scaffold c-Src/Vav signaling in vitro; leaves open cardiovascular disease relevance and therapeutic targeting.

Population

In vitro and in vivo cell extracts and protein models (hnRNP K protein)

Intervention

Mapping of K protein domains that bind kinases

Outcome

Identification of SH3-binding sites and the domain that recruits the IL-1-responsive K protein kinase (KPK)surrogate

The K protein may serve as a docking platform that promotes molecular interactions during signal transduction by forming multienzyme complexes.

Seuningen et al. (1995) studied this question.

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