The Kinase Insert Domain of Interferon-induced Protein Kinase PKR Is Required for Activity but Not for Interaction with the Pseudosubstrate K3L

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Population

In vitro and in vivo models studying Interferon-induced protein kinase (PKR)

Comparison

Deletions and point mutations within the kinase… vs Wild-type PKR

Design

Preclinical

Authors

Discussion

These domain distinctions in PKR merit further mechanistic studies; leaves open applicability to human cardiovascular or inflammatory conditions.

Population

In vitro and in vivo models studying Interferon-induced protein kinase (PKR)

Intervention

Deletions and point mutations within the kinase insert domain of PKR (including mutation of serine 355)

Comparator

Wild-type PKR

Outcome

Kinase activity and binding of the pseudosubstrate inhibitor K3Lsurrogate

The kinase insert domain of PKR is essential for its catalytic activity but not for its interaction with the pseudosubstrate K3L.

Craig et al. (1996) studied this question.

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These domain distinctions in PKR merit further mechanistic studies; leaves open applicability to human cardiovascular or inflammatory conditions.