Why the study?
Does experimental pulmonary embolism alter the gene expression of ANP, BNP, and ET-1 in the cardiac chambers of rats?
Does experimental pulmonary embolism alter the gene expression of ANP, BNP, and ET-1 in the cardiac chambers of rats?
Experimental pulmonary embolism in rats causes a dose-dependent increase in ANP and BNP gene expression selectively in the right ventricle, supporting their use as biomarkers for right ventricular dysfunction.
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May support ANP/BNP as RV strain biomarkers; hypothesis-generating in rats, requires human validation before clinical use.
Gutte et al. (2010) studied this question.
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