What is the clinical evidence from this study?

Study design: Observational. Population: Pulmonary embolism. Intervention: Plasma concentration of D-dimer, pro-ANP, BNP, ET-1 and TNI. Primary outcome: Right ventricular dysfunction (RVD).

What question did this study set out to answer?

This research aims to predict right ventricular dysfunction (RVD) using various cardiac biomarkers in patients with pulmonary embolism (PE).

August 19, 2010Clinical Physiology and Functional Imaging

ANP, BNP and D‐dimer predict right ventricular dysfunction in patients with acute pulmonary embolism

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Key result

Elevated plasma concentrations of D-dimer, pro-ANP, and BNP were accurate for the detection of right ventricular dysfunction in patients with pulmonary embolism.

Why the study?

Do plasma concentrations of D-dimer, pro-ANP, BNP, ET-1, and TNI predict right ventricular dysfunction in patients with acute pulmonary embolism?

Key Points

This research aims to predict right ventricular dysfunction (RVD) using various cardiac biomarkers in patients with pulmonary embolism (PE).
Patients suspected of PE underwent V/Q-SPECT, multidetector CT angiography, and blood sampling on the same day.
Cardiac biomarkers including D-dimer, pro-ANP, and BNP were measured and analyzed.
ROC curves were utilized to assess the accuracy of biomarkers for detecting RVD.
Pro-ANP, BNP, and D-dimer levels were significantly elevated in PE patients presenting with RVD.
ROC analysis showed D-dimer, pro-ANP, and BNP are accurate for predicting RVD in PE patients.
Despite promising results, confirmation in larger studies is necessary due to the small sample size.

Study Design

Type

Observational

Structured PICO

Do plasma concentrations of D-dimer, pro-ANP, BNP, ET-1, and TNI predict right ventricular dysfunction in patients with acute pulmonary embolism?

Population

Patients suspected of pulmonary embolism evaluated for right ventricular dysfunction using cardiac biomarkers.

Exposure

Measurement of plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI)

Outcome

Detection of right ventricular dysfunction (RVD)surrogate

Pro-ANP, BNP, and D-dimer are accurate and easily obtained biomarkers for detecting right ventricular dysfunction in patients with acute pulmonary embolism.

Limitations

Small sample size
small sample size

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support noninvasive RV dysfunction detection in acute PE; leaves open prospective validation before clinical adoption.

Cite This Study

Gutte et al. (2010) conducted an observational in Pulmonary embolism. Plasma concentration of D-dimer, pro-ANP, BNP, ET-1 and TNI was evaluated on Right ventricular dysfunction (RVD). Elevated plasma concentrations of D-dimer, pro-ANP, and BNP were accurate for the detection of right ventricular dysfunction in patients with pulmonary embolism.

synapsesocial.com/papers/6a221be300d082f62f970be7 https://doi.org/10.1111/j.1475-097x.2010.00967.x

Topics

Pulmonary embolism

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ANP, BNP and D‐dimer predict right ventricular dysfunction in patients with acute pulmonary embolism

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

ANP, BNP and D‐dimer predict right ventricular dysfunction in patients with acute pulmonary embolism

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider