What question did this study set out to answer?

This research aimed to evaluate the role of cardiac biomarkers and right ventricular dysfunction in predicting short-term mortality in patients with acute pulmonary embolism.

December 31, 2014Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology

Evaluation of cardiac biomarkers and right ventricular dysfunction in patients with acute pulmonary embolism

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Population

41 patients with confirmed acute pulmonary embolism, mean age 60.5±13.8 years. Grouped into massive…

Design

Cohort, investigators blinded to the biomarker levels

Follow-up

6 months

Authors

NDNeşe DursunoğluAmerican College of Chest Physicians DDDursun DursunoğluPamukkale University AYAli İhsan YıldızPamukkale University

Discussion

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Implication

May inform mortality risk stratification in acute PE; hypothesis-generating and requires prospective validation before practice change.

Key Points

This research aimed to evaluate the role of cardiac biomarkers and right ventricular dysfunction in predicting short-term mortality in patients with acute pulmonary embolism.
Analyzed 41 patients with confirmed acute pulmonary embolism prospectively.
Patients classified into three groups based on blood pressure and right ventricular dysfunction assessed by transthoracic echocardiography.
Analyzed cardiac troponin T, NT-proBNP, and HFABP concentrations at baseline and followed up for 6 months.
41.5% of patients experienced complications in the 6-month follow-up, including 29.3% mortality (12 deaths, 3 PE-related).
Multivariate hazard ratio analysis identified HFABP, NT-proBNP, and pulmonary artery pressures as significant predictors of 6-month mortality (HR 1.02, 95% CI 1.01-1.05; HR 1.01, 95% CI 1.01-1.04; HR 1.02, 95% CI 1.02-1.05, respectively).

Structured PICO

Population

41 patients with confirmed acute pulmonary embolism (24 females, 17 males), mean age 60.5±13.8 years. Grouped into massive (n=18), submassive (n=4), and non-massive (n=19) PE based on systemic systolic blood pressure and right ventricular dysfunction.

Outcome

Combined end-point in the 6-month follow-up including at least one of the following: death, chronic PE, pulmonary hypertension, and recurrent PEcomposite

Elevated levels of HFABP, NT-proBNP, and pulmonary artery pressures measured on admission are significant predictors of 6-month mortality in patients with acute pulmonary embolism.

Limitations

small number of patients (especially in the massive PE group)
NT-proBNP for the diagnosis of RVD in acute PE has low specificity

Cite This Study

Dursunoğlu et al. (2014) studied this question.

synapsesocial.com/papers/6a22e0ab4b8f7db2bfc46bea https://doi.org/10.5152/akd.2014.5828

Topics

Pulmonary embolism Echocardiography

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Evaluation of cardiac biomarkers and right ventricular dysfunction in patients with acute pulmonary embolism

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Evaluation of cardiac biomarkers and right ventricular dysfunction in patients with acute pulmonary embolism

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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Topics

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