Key result
The presence of right ventricular dysfunction determined by echocardiography (OR 2.36) or elevated natriuretic peptides (OR 7.7) was associated with increased short-term mortality in patients with pulmonary embolism without hemodynamic compromise.
Why the study?
Does the presence of right ventricular dysfunction predict short-term mortality in patients with pulmonary embolism without hemodynamic compromise?
Population
Patients with acute pulmonary embolism without hemodynamic compromise. 15 studies included.
Comparison
Presence of right ventricular dysfunction as… vs Absence of right ventricular dysfunction
Design
Meta-analysis
Follow-up
up to 3 months
Authors
Loading...
May inform closer monitoring in higher-risk normotensive PE; confirms prognostic associations yet leaves open utility for guiding therapy.
Meta-Analysis (n=2,334)
Does the presence of right ventricular dysfunction predict short-term mortality in patients with pulmonary embolism without hemodynamic compromise?
Odds Ratio: 2.36 (95% CI 1.3–4.3)
Echocardiographic right ventricular dysfunction and elevated natriuretic peptides are associated with short-term mortality in normotensive pulmonary embolism, but their clinical utility for risk stratification is limited by poor likelihood ratios.
Coutance et al. (2011) conducted a meta-analysis in Pulmonary embolism without hemodynamic compromise (n=2,334). Right ventricular dysfunction (assessed by echocardiography) vs. Absence of right ventricular dysfunction was evaluated on All-cause mortality within 3 months (OR 2.36, 95% CI 1.3-4.3). The presence of right ventricular dysfunction determined by echocardiography (OR 2.36) or elevated natriuretic peptides (OR 7.7) was associated with increased short-term mortality in patients with pulmonary embolism without hemodynamic compromise.