Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1999Cardiovascular ResearchOpen Access

Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) gene products are regulated post-transcriptionally during rat cardiac development

View Full Paper
Ask AI
Bookmark
Share

Authors

ADAntoine Ribadeau Dumas

Discussion

Loading...

Member takes

Overview

Post-transcriptional SERCA2 regulation in rats leaves open clinical translation to human HF; hypothesis-generating for targeted therapies.

Key Points

  • This study aims to determine how the increase in SERCA2 mRNA during perinatal development is regulated.
  • Nuclear run-on assays were used to assess transcriptional activity.
  • mRNA and protein levels were measured throughout late fetal and early neonatal stages in rats.
  • Protein levels of SERCA2 and myosin heavy chains were analyzed during cardiac development.
  • SERCA2 transcription levels did not differ significantly between embryonic and neonatal stages (139 +/- 41 ppm at 17/18 days, 139 +/- 37 ppm at 20 days; n=6-7).
  • SERCA2 mRNA levels significantly increased from 15 +/- 3.8 A.U. at birth to a maximum of 48.3 +/- 7.0 A.U. by 20 days of age.
  • Protein levels of SERCA2 increased from 1.13 +/- 0.13 A.U./microgram in fetus to 2.98 +/- 0.17 A.U./microgram by day 20.

Cite This Study

Antoine Ribadeau Dumas (1999) studied this question.

synapsesocial.com/papers/6a7253b875498292b70b7627https://doi.org/10.1016/s0008-6363(99)00120-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium accumulating and ATPase activity of cardiac sarcoplasmic reticulum before and after birth1977 · 88 citations
  2. 2Differentiation of sarcoplasmic reticulum during cardiac myogenesis1987 · 65 citations
  3. 3Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart1997 · 30 citations
  4. 4Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.1990 · 341 citations
  5. 5Developmental changes in myocardial mechanical function and subcellular organelles1984 · 131 citations