What is the clinical evidence from this study?

Population: Congestive heart failure. Intervention: Congestive heart failure. Primary outcome: SERCA gene and protein expression.

November 1, 1997Circulation Research

Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase Gene Expression in Congestive Heart Failure

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Key result

Congestive heart failure in rats was associated with decreased SERCA1 mRNA and protein levels in multiple skeletal muscles, contributing to contractile abnormalities.

Authors

DPDavid G. PetersUniversity of Pittsburgh HMHeather L. MitchellGoogle (United States)SMSylvia A. McCuneUniversity of Colorado Boulder

Discussion

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Implication

Should not alter heart failure management; leaves open SERCA1 as a therapeutic target in human skeletal myopathy.

PICO

Population

Spontaneous hypertensive and heart failure rats evaluated for skeletal muscle SERCA gene expression.

Exposure / Comparator

Congestive heart failure

Primary Outcome

SERCA gene and protein expression

Cite This Study

Peters et al. (1997) studied Congestive heart failure. Congestive heart failure was evaluated on SERCA gene and protein expression. Congestive heart failure in rats was associated with decreased SERCA1 mRNA and protein levels in multiple skeletal muscles, contributing to contractile abnormalities.

synapsesocial.com/papers/6a9d83057ce56dd70348b672 https://doi.org/10.1161/01.res.81.5.703

Topics

Heart failure HFrEF treatment

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Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase Gene Expression in Congestive Heart Failure

Discussion

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Implication

PICO

Cite This Study

Topics

Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase Gene Expression in Congestive Heart Failure

Discussion

Member takes

Implication

PICO

Cite This Study

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