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The bone of rats made chronically uremic by segmental infarction of one kidney and contralateral nephrectomy exhibited a decrease in mature collagen and an increase in early soluble collagen content, suggesting a maturation block in bone collagen induced by the uremic state. The mature and soluble collagen contents of skin in uremic rats was unchanged. Kinetic studies of bone collagen formation with proline tagged with carbon 14 revealed both a decrease in collagen maturation and demonstrated an increase in mature collagen degradation.
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Theodore J. Hahn (1970) studied this question.
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