Why the study?
The extent to which left ventricular mass and remodelling account for blood pressure-associated alterations in left ventricular diastolic function is uncertain.
Population
709 randomly selected community participants with a 49.6% prevalence of hypertension
Comparison
Impact of blood pressure on diastolic function mediated by LVMI or RWT vs not
Design
Community-based cross-sectional study using product of coefficient mediation analysis
Authors
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LVM and remodelling explain little of BP effects on diastolic function; leaves open other pathways for hypothesis-generating research.
Structural left ventricular remodeling accounts for only a minor proportion of the impact of blood pressure on diastolic function, suggesting that blood pressure-associated diastolic dysfunction occurs largely independent of LV hypertrophy.
Bamaiyi et al. (2019) studied this question.
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