What question did this study set out to answer?

July 1, 2002British journal of surgeryOpen Access

Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm

View Full Paper

Ask AI

Bookmark

Why the study?

Does ultrasonographic screening reduce mortality from abdominal aortic aneurysm in men aged 65 years and over?

Population

6,058 men aged 65 years and over

Comparison

Invitation to attend ultrasonographic screening… vs Control group (no invitation to screening)

Design

RCT, Randomized to a group invited to attend ultrasonographic screening or to…

Follow-up

10 years

Authors

KVKaterina VardulakiNational Audit Office NWNeil WalkerAutism Partnership Foundation ECE. CoutoFundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Discussion

Member takes

Implication

Invitation to AAA screening yields non-significant 10-year mortality reduction; leaves open whether improved adherence can sustain the 4-year peak benefit.

Key Points

To assess the 10-year efficacy, feasibility, and compliance of ultrasonographic screening for abdominal aortic aneurysm and determine reasons for intervention failure.
Randomized trial allocating 6,058 men aged 65 years and older to either an invitation for ultrasonographic screening or a control group.
Mortality from abdominal aortic aneurysm over 10 years of follow-up was analyzed on an intention-to-treat basis using a Poisson model.
Ultrasonographic screening was associated with a 21% reduction in abdominal aortic aneurysm mortality over 10 years (RR 0.79, 95% CI 0.53 to 1.40), with relative mortality reduction peaking at 52% at 4 years.
Among the 24 abdominal aortic aneurysm deaths in the screened arm, 18 occurred in men who did not attend their initial scan or failed to comply with follow-up protocols.

Structured PICO

Does ultrasonographic screening reduce mortality from abdominal aortic aneurysm in men aged 65 years and over?

Population

6,058 men aged 65 years and over

Intervention

Invitation to attend ultrasonographic screening for abdominal aortic aneurysm

Comparator

Control group (no invitation to screening)

Outcome

Mortality rate from abdominal aortic aneurysmhard clinical

Ultrasonographic screening for AAA in men aged 65 and older showed a non-statistically significant 21% reduction in AAA mortality at 10 years, though the benefit was heavily attenuated by patient non-compliance.

Limitations

High rate of non-compliance (18 of 24 AAA deaths in the study group were among those who did not attend the first screen or failed to comply with follow-up)

Cite This Study

Vardulaki et al. (2002) studied this question.

synapsesocial.com/papers/6a725741e36a167817e3ceed https://doi.org/10.1046/j.1365-2168.2002.02133.x

View Full Paper

Ask AI

Bookmark

Implication

Invitation to AAA screening yields non-significant 10-year mortality reduction; leaves open whether improved adherence can sustain the 4-year peak benefit.

Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider