June 29, 2005Diabetic Medicine

Insulin sensitivity independently influences brachial–ankle pulse‐wave velocity in non‐diabetic subjects

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Why the study?

Is insulin sensitivity independently associated with brachial-ankle pulse-wave velocity in non-diabetic subjects?

Structured PICO

Is insulin sensitivity independently associated with brachial-ankle pulse-wave velocity in non-diabetic subjects?

Population

1541 non-diabetic Japanese subjects undergoing health examinations, excluding those with chronic or acute inflammation, malignant diseases, autoimmune disorders, elevated serum creatinine levels, abnormal hepatic function tests, or ankle/brachial blood pressure index < 0.9.

Outcome

Relationship between homeostasis model assessment insulin sensitivity index (HOMA-%S) and brachial-ankle pulse-wave velocity (PWV)surrogate

Insulin resistance is independently associated with increased arterial stiffness, as measured by pulse-wave velocity, in non-diabetic individuals.

Authors

SKSoji KasayamaNippon Medical School Hospital HSHiroshi SaitōKameda Medical Center MMMikio MukaiOsaka International Cancer Institute

Discussion

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Implication

Supports further investigation of insulin sensitivity in arterial stiffness; cross-sectional data leave causality and intervention effects open.

Cite This Study

Kasayama et al. (2005) studied this question.

synapsesocial.com/papers/6a7259695d37378ac1df2aa8 https://doi.org/10.1111/j.1464-5491.2005.01718.x

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Implication

Supports further investigation of insulin sensitivity in arterial stiffness; cross-sectional data leave causality and intervention effects open.