Key result
Elevated ADMA (coefficient +2.57) and LDL-cholesterol levels were independently associated with increased arterial stiffness among pre-diabetic subjects, whereas exercise was inversely correlated.
Population
53 prediabetic individuals, mean age 50.6, 54.7% female, from a tertiary urban Greek hospital.
Design
Cross-sectional
Authors
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Findings hypothesis-generating only; extends cross-sectional links in pre-diabetes but requires longitudinal trials before clinical consideration.
Cross-Sectional (n=53)
No
Effect estimate: coefficient +2.57 (for ADMA) (95% CI 0.84-4.31)
p-value: p=0.004
Elevated ADMA and LDL-C levels are strongly associated with increased arterial stiffness among pre-diabetic subjects, whereas exercise is inversely correlated.
Protopsaltis et al. (2012) conducted a cross-sectional in Pre-diabetes (n=53). ADMA, LDL-cholesterol, and exercise was evaluated on Carotid-femoral pulse wave velocity (PWV) (coefficient +2.57 (for ADMA), 95% CI 0.84-4.31, p=0.004). Elevated ADMA (coefficient +2.57) and LDL-cholesterol levels were independently associated with increased arterial stiffness among pre-diabetic subjects, whereas exercise was inversely correlated.
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