Key result
Prediabetes was associated with higher pulse wave velocity compared to normoglycemia, with the highest values seen in uncontrolled hypertension.
Why the study?
Pulse wave velocity is a known predictor of target organ damage, cardiovascular disease, and overall mortality, but PWV values needed comparison among subjects with prediabetes, a non-dipper profile, and arterial hypertension versus healthy subjects.
Do prediabetes and a non-dipping blood pressure profile increase arterial stiffness (pulse wave velocity) in subjects with and without hypertension?
Cross-Sectional (n=301)
Do prediabetes and a non-dipping blood pressure profile increase arterial stiffness (pulse wave velocity) in subjects with and without hypertension?
Prediabetes and a non-dipping blood pressure profile are associated with increased arterial stiffness, independent of hypertension control.
Answers are grounded in this paper and cite their sources.
Supports vascular assessment in prediabetes; leaves open causal effects and intervention benefits.
Background: Pulse wave velocity (PWV) is a known predictor of target organ damage, cardiovascular disease and overall mortality. The aim of this study was to compare the PWV values in subjects with prediabetes, a non-dipper profile and arterial hypertension with their values in healthy subjects. Methods: A total of 301 subjects, aged 40–70 years, without diabetes mellitus were included in this cross-sectional study (150 with prediabetes). They underwent a 24 h ambulatory blood pressure monitoring (ABPM). Subjects were divided into three hypertension groups (A = healthy, B = controlled hypertension, C = uncontrolled hypertension). Dipping status was determined according to ABPM results, and PWV was measured by an oscillometric device. Prediabetes was defined as having 2 separate fasting plasma glucose (FPG) measurements between 5.6 and 6.9 mmol/L. Results: The highest PWV values were found in group C (9.60 ± 1.34 vs. 8.46 ± 1.01 in group B vs. 7.79 ± 1.10 in group A; p < 0.001), in subjects with prediabetes (8.98 ± 1.31 m/s vs. 8.26 ± 1.22 m/s; p < 0.001) and in prediabetic non-dippers among age groups (p = 0.05). In the multivariate regression model age, blood pressure, nocturnal indices and FPG were shown as independent predictors of PWV values. Conclusion: Significantly higher PWV values were found in subjects with prediabetes and non-dipping profiles in all three examined hypertension groups.
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Jug et al. (2023) conducted a cross-sectional in Prediabetes and hypertension (n=301). Prediabetes vs. Normoglycemia was evaluated on Pulse wave velocity (PWV) (p=<0.001). Prediabetes was associated with higher pulse wave velocity compared to normoglycemia, with the highest values seen in uncontrolled hypertension.
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