Why the study?
Does activated charcoal reduce QT interval prolongation and the risk of abnormal QT-RR combinations in patients following citalopram overdose?
Population
52 patients presenting to a tertiary toxicology unit after deliberate self-poisoning with citalopram. Median…
Comparison
Single dose of activated charcoal administered… vs No activated charcoal administered.
Design
Cohort
Follow-up
up to 81.5 hours
Authors
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May support activated charcoal after high-dose citalopram overdose; hypothesis-generating and requires randomized confirmation before practice change.
Does activated charcoal reduce QT interval prolongation and the risk of abnormal QT-RR combinations in patients following citalopram overdose?
In patients with citalopram overdose, administration of activated charcoal significantly reduces QT prolongation and the surrogate risk for torsade de pointes, particularly at doses exceeding 600 mg.
Friberg et al. (2005) studied this question.
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