Citalopram overdose can cause significant cardiovascular toxicity including QTc prolongation and ventricular fibrillation.
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Serial citalopram monitoring may inform overdose care; hypothesis-generating from single case, needs prospective validation.
Selective serotonin reuptake inhibitors are widely prescribed drugs without recognized cardiovascular risk. We report the case of a 54-year-old patient who developed QTc interval prolongation, followed by ventricular fibrillation episodes, 10 hours after admission to the ICU, in the setting of a citalopram overdose. Citalopram plasma values dropped from 5.88 to 0.34 mg/L at 9 days postadmission. The patient was treated by oral activated charcoal, and final outcome was favorable.
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Liotier et al. (2011) studied this question.
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